The rash may even spread into the mouth or other internal parts of the body. In people who have been infected, symptoms appear between 10 and 21 days after exposure to varicella virus. The severity of the rash of shingles seems to play no role. The Shingles symptoms pain can be relieved with the help of anti-depressants (tricyclic). These substances are intended to modify the abnormal nerve impulses. However, in some cases, the use of opiates as powerful as morphine will be needed. A rash of shingles can last four to five weeks if not treated. Since the vesicles are located in the path of nerves, shingles is usually very painful. Among black people, such vesicles can leave large scars, termed keloid.